There's a gem of a skill called Pain Inverter that makes the Great Destroyer a joke. Unless they nerfed it since my last login, and it's been a great while, it's a great option if cheap tactics don't bother you (definitely saves the hairline some!). The trick is to be fast and have enough heros and familiars within range to invert sufficient damage. Consider bringing an SS ritualist, MM necromancer and rangers with an animal companion with you.